Newborns at risk of type 1 diabetes from having received antibiotics could recover their intestinal microorganisms with a maternal fecal transplant, according to a study by Rutgers University, in the United States, and published in the journal Cell Host & Microbe.
The results suggest that newborns who are at risk of type 1 diabetes because their microbiome (the billions of beneficial microorganisms in our body) has been altered, can reverse the disease by transplanting fecal microbiota from his mother to his gastrointestinal tract after the completion of antibiotic treatment. Type 1 diabetes is the most common autoimmune disease in childhood.
“Our previous work has shown that exposing young animals to antibiotics disrupts the microbiome, which can change age-associated immunity and organ-specific inflammation, increasing the risk of immune-mediated diseases,” explains co-author Martin Blaser. , director of the Rutgers Center for Biotechnology and Advanced Medicine.
Maternal microbiota transplantation
The study compared mice that were exposed to antibiotics between days 5 and 10 of life and received a maternal microbiota transplant for up to a week later, and those that were not. The researchers found that the transplanted mice had their microbiome partially restored and the risk of diabetes returned to baseline.
“Mice exposed to antibiotics had reporter gene expression in their gut wall too high or too low, but transplantation brought it back almost to original levels and restored metabolic pathways,” says co-author Xue-Song Zhang, assistant professor. research at the Rutgers Center for Biotechnology and Advanced Medicine. “We were able to identify groups of genes that returned to normal after transplantation as if the mice had never received the antibiotics,” he concludes.
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