HPV Test And Cytology Double The Chance Of Detecting Cervical Cancer Early, According To Study

The goal of testing is to find precancer and cancer early when it is most treatable and curable.

Cervical cancer treatment plan for internal radiation therapy. The dose distribution around the tumor is shown in red. The normal structure, such as the bladder and rectum, are contoured. Photo:

This study indicates and confirms what was recently published by the US screening standards, it is a study that indicates that the combination of detection based on high-risk human papillomavirus (hrHPV) with cytological triage detected twice as many cases of grade 2+ cervical intraepithelial neoplasia (CIN2 +) than cytology alone.


“Our results provide evidence that hrHPV testing is the best strategy for early diagnosis of CIN2 + lesions while avoiding overtreatment of young women. Many countries now use hrHPV testing as the primary screening method, given that it has higher sensitivity and detects more cervical cancer precursor lesions, such as CIN2 +, “said study author Erik Jansen.

Research conducted by the Mexican Institute of Public Health confirms the importance of HPV detection for the early detection of high-grade cervical lesions.

“The significance of this document is that the reported data comes from long-term follow-up in a country that implemented HPV screening on a large scale,” said Jansen, PhD candidate in the Department of Public Health, Erasmus University Medical Center. , Rotterdam, the Netherlands.

Among other aspects, they point out the importance of including this type of exams in public health plans that facilitate detection in this population.

What is cervical cancer?

Cervical cancer or cervical cancer originates in the cells that line the cervix, the lower part of the uterus, and according to the American Cancer Society, the cervix is ​​made up of two parts and is covered with two different types of cells.

The endocervix: it is the opening of the cervix that leads to the uterus, and which is covered with glandular cells.

The ectocervix (or ectocervix) is the outer part of the cervix that a doctor can see during a speculum exam (Pap test), and which is covered in squamous cells.

Types of cervical cancer

Cervical cancers and pre-cancers are classified by how they appear when viewed under a microscope in the laboratory. The two most common types of cervical cancers are squamous cell carcinoma and adenocarcinoma.

The majority (9 out of 10 cases) of cervical cancers are squamous cell carcinomas. These cancers develop from cells in the exocervix. Squamous cell carcinomas most often originate in the transformation zone (where the exocervix joins the endocervix).

Most other cervical cancers are adenocarcinomas that originate from glandular cells. Cervical adenocarcinoma originates in the cells of the mucus-producing glands of the endocervix.

Cervical cancer that has characteristics of both squamous cell carcinomas and adenocarcinomas is less common. These tumors are called adenosquamous carcinomas or mixed carcinomas.

Although almost all cervical cancers are squamous cell carcinomas or adenocarcinomas, other types of cancer can also develop in the cervix. These other types, such as melanoma, sarcoma, and lymphoma, occur more often in other parts of the body.

Research consulted here.

Definition consulted here.